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Single chemical group helps RNA form protective droplets before first cells

University at Buffalo scientists report that a specific oxygen-containing group in RNA may explain how early molecules formed protective structures on October 1, 2026.

One tiny chemical difference between RNA and DNA may help explain how life began
File photo One tiny chemical difference between RNA and DNA may help explain how life began Photo: ScienceDaily

RNA forms liquid-like protective clusters

New research indicates RNA molecules can assemble into tiny liquid-like droplets that concentrate other molecules. These condensates do not require membranes to gather RNA in one specific location. Such structures could have provided necessary protection for fragile molecules in harsh early environments.

One chemical difference drives behavior

Scientists found a single oxygen-containing chemical group present in RNA but absent in DNA is likely responsible. This feature allows the molecules to harden into gel-like structures that shield their contents. The discovery addresses how RNA survived without cellular compartments before life began.

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