New study reveals how mechanical force changes talin protein binding
Researchers at Tampere University published a study in the Proceedings of the National Academy of Sciences describing a new mechanism for the talin protein.
Force exposes hidden binding sites
Mechanical pressure applied to talin alters its structure and reveals a previously unknown region. This exposed area allows talin molecules to attach directly to one another under load. The discovery challenges earlier beliefs about which parts of the protein bind to integrins.
Recruitment strengthens cell adhesion
Binding between talin molecules recruits additional units to the adhesion sites on the cell membrane. This process may help reinforce structures that cells use to attach to their surroundings. The mechanism explains how cells sense and respond to stretching or pressure.
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