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Researchers created healthy calves without essential embryonic protein

Scientists at LMU Munich reported on February 26, 2026, that two female calves were born after researchers used gene editing to remove interferon tau genes.

Cows deliver healthy calves without embryonic protein long thought essential for pregnancy
File photo Cows deliver healthy calves without embryonic protein long thought essential for pregnancy Photo: Phys.org

New method challenges old belief

For decades, experts assumed a specific protein was required for cattle pregnancies to succeed. A team led by Dr Asghar Ali removed all functional copies of the IFNT genes using CRISPR technology. The resulting embryos developed normally during their earliest stages despite lacking this signal.

Cloned embryos transferred to mothers

Researchers generated cloned embryos from these modified cell nuclei and placed them inside recipient animals. On February 26, 2026, two healthy female calves were born from these pregnancies. Both newborns were confirmed to lack the functional genes that produce interferon tau.

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