Georgia Tech researchers develop biodegradable STAR particles for skin drug delivery
Georgia Tech professor Mark Prausnitz and his team have developed tiny biodegradable particles that create microscopic openings in the skin to improve topical medicine absorption.
New method bypasses skin barrier
The skin naturally blocks most medicines intended for direct application. These new particles mix into creams or gels to overcome that resistance. When rubbed across the skin, they form microscopic pathways for medication.
Design resembles medieval weapons
Prausnitz describes the particles as looking like a tiny porcupine or a ball and chain with spikes. Each particle projects microneedles that function like points on a star. The work has been published in the journal Advanced Healthcare Materials.
Evolution from microneedle patches
This technology grew out of existing microneedle patches used for small treatment areas. The new particles aim to simplify delivery by avoiding the need for adhesive patches. Swallowing a pill currently requires the drug to travel through the stomach before reaching skin issues.
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