Brain enzyme linked to cognitive resilience in aging mice and humans
Researchers reported on October 15 that a specific brain enzyme helps preserve cognitive function and reduce inflammation in aging models.
Study findings across species
High levels of this enzyme correlate with low inflammation in the brains of aged mice. The research also demonstrated that the enzyme boosts neuron growth in ageing brains. These results were published in Nature Neuroscience on October 15.
Enzyme function explained
The enzyme in question is a phospholipase that breaks down fatty compounds. Study co-author Amar Sahay describes it as a compensatory cognitive-resilience mechanism. Timothy Hohman noted the approach uses model systems to study resilience mechanisms difficult to observe in humans.
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