Researchers validate new platform for manufacturing extracellular vesicles from umbilical cord cells
A study led by researchers at the Germans Trias i Pujol Research Institute and the Blood and Tissue Bank has validated a semiautomated platform for producing extracellular vesicles that meets pharmaceutical quality requirements.
Study published in scientific journal
The team published their findings in the journal iScience. Their work focuses on vesicles derived from mesenchymal stromal cells found in umbilical cords. These particles carry molecules that can modulate cellular responses such as inflammation.
Manufacturing process combines culture and purification
The developed system uses a bioreactor-based culture system alongside two consecutive concentration techniques. Chemically defined conditions free from animal-derived components were used throughout the production cycle. This approach ensures consistent batches suitable for potential regenerative therapies.
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