Researchers use light-emitting nanoparticles to guide ultrasound for precise gene editing in mouse brains
Scientists at the Wu Tsai Neurosciences Institute demonstrated a new method using light-emitting nanoparticles and ultrasound to edit genes in specific regions of mouse brains without surgery or implants.
New technique avoids invasive procedures
The team combined ultrasound, light-emitting nanoparticles, and photo-controllable gene-editing proteins to alter genes at selected locations. This approach allows researchers to target specific areas deep within the brain and body. Previous methods often required invasive techniques like implanted nanoscaffolds to achieve similar targeting.
Study published in Cell journal
Guosong Hong led the research alongside Michael Lin from Stanford Engineering and Stanford Medicine. The work represents a significant advance in controlling CRISPR-family gene editors for localized treatment. Researchers hope this method will help treat conditions like chronic pain without affecting other body parts.
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