Researchers image ribosome assembly inside human cells for first time
A collaboration between research groups at EMBL Heidelberg published detailed images of ribosome assembly inside intact human cells in the journal Science.
New imaging technique used
Researchers combined cryo-electron tomography with correlative light and electron microscopy to achieve high resolution. This approach allowed them to visualize the nucleolus where ribosomes form within living cells. The method produced subnanometer-resolution structures of many intermediates along the assembly pathway.
Previous knowledge expanded
The study complements earlier insights that were obtained from structures outside their native cellular context. Scientists had previously discovered many underlying mechanisms for building ribosomes but lacked in situ understanding. These new results expand the collection of molecular snapshots available to the scientific community.
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