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New experiments show two cell types build the human brain

Researchers at Stanford University published findings today in Nature Neuroscience stating that distinct progenitor cells form different parts of the brain.

How to make a brain: new experiments challenge existing picture
File photo How to make a brain: new experiments challenge existing picture Photo: Nature

Old theory faces new evidence

Scientists previously believed one starter cell created the entire organ. Current work suggests two flavours of progenitor cell are required instead. One type forms the hindbrain while another generates the forebrain and midbrain.

Specific structures get specific cells

The hindbrain handles basic functions like heartbeat and breathing according to the study. A second precursor population creates the forebrain for reasoning and the midbrain. These parts connect and work together despite coming from separate sources.

Methodology draws broad praise

The team developed an efficient method to grow hindbrain motor-neuron cells. This technique helps control movements such as swimming in model organisms. Some experts still debate whether the two cell populations truly do not mix.

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