New CRISPR tool helps researchers mutate bacteriophages at University of Otago
Researchers at the University of Otago in New Zealand have developed a new method to mutate bacteriophages using CRISPR-Cas technology.
Method enables genome-wide analysis
The new tool allows for genome-wide mutagenesis of bacteriophages. This approach uses transposon insertion sequencing to identify unknown genes. The technique helps scientists understand functions previously classified as microbial dark matter.
Potential applications in health
Professor Peter Fineran states that phages have huge potential to combat antimicrobial resistance. The method supports sustainable agriculture by offering an alternative to agrochemicals. Understanding these viruses could improve their use in healthcare and biotechnology.
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