Gut bacteria metabolites extend fruit fly lifespan in Japan study
Researchers in Japan found that polyamines produced by gut bacteria can directly increase the lifespan of fruit flies.
Study team investigates bacterial metabolites
A research team led by Associate Professor Shin Kurihara and Professor Takayuki Kuraishi used genetically engineered flies to test specific bacteria. They compared flies with bacteria that produce polyamines against those with modified bacteria that lack this production capability. The scientists aimed to determine if these metabolites influence host lifespan independently of dietary sources.
Polyamines linked to longer life
The researchers utilized gnotobiotic flies colonized with genetically engineered Escherichia coli to isolate the effects of bacterial activity. Flies carrying bacteria capable of producing polyamines showed improved biological functions compared to controls without these metabolites. This experimental system allowed the team to confirm that gut microbial activity directly affects host physiology.
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