AI analysis of Reddit posts finds unexpected Ozempic side effects
A University of Pennsylvania team used artificial intelligence to review 400,000 Reddit posts on September 13, 2026, identifying potential side effects for GLP-1 drugs.

Study examines millions of user reports
Researchers analyzed data from nearly 70,000 Reddit users over a five-year period. The analysis covered posts regarding semaglutide and tirzepatide medications including Ozempic, Wegovy, Mounjaro, and Zepbound. These findings were published recently in the journal Nature Health.
Specific symptoms require further investigation
The study highlighted reproductive issues such as changes in menstrual cycles as a key area of concern. Users also reported body temperature problems including chills and hot flashes alongside general fatigue. The team noted that these patterns might represent signals missed during clinical trials.
Causation remains unproven by data
The researchers stated they cannot say the medications caused these specific problems based on the current evidence. However, the identified patterns suggest overlooked symptoms worth studying in future research. Official regulatory information may not fully represent what patients experience online.
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