Researchers use 3D models to show pressure kills cancer cells
Scientists published a study in Developmental Cell on October 14 showing that sustained pressure stops cancer cell migration and triggers death in three-dimensional lab models.
Study shifts from flat cultures
Previous research primarily examined cancer growth using two-dimensional cell cultures. This new work instead utilized three-dimensional models to observe how mechanical confinement affects the cells.
Pressure acts as danger signal
Cancer cells proliferate and move within tight spaces while facing increasing pressure inside solid tumors. The study suggests these cells interpret that abnormal physical environment as a warning sign.
Potential for new biomarkers
The findings might help create tools to predict which cancers are likely to spread. Researchers hope this knowledge will eventually lead to methods for preventing metastasis.
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