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Researchers create largest map of human prefrontal cortex gene activity

A consortium of US institutions has released a new map of human brain gene activity based on data from nearly 1,500 people.

Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more
File photo Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more Photo: Nature

New map covers six million cells

The project analyzed sequencing data from more than six million individual cells. This collection comes from almost 1,500 individuals and focuses on the prefrontal cortex area.

Study aims to inform disease research

Panos Roussos of the Icahn School of Medicine at Mount Sinai says the work began in 2019. The PsychAD Consortium, which is funded by the NIH, produced nine papers describing the findings.

Experts note unprecedented scale

Zhichao Miao from the Guangzhou National Laboratory stated that single-cell studies have traditionally used smaller numbers of individuals. This population-scale setting allows researchers to ask new kinds of questions about neurodegenerative and psychiatric diseases.

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