Renal cancer researchers create tumour assembloids to study immune cell interactions
Scientists have developed new tumour assembloids to model how renal cancer cells, fibroblasts and T cells interact in humanized mouse models.
New platform for complex cancer models
Researchers generated combinatorial mix-and-match structures containing multiple components of human renal cell carcinoma. These models include cancer cells, cancer-associated fibroblasts and tumour-infiltrating immune cells within a single system.
Signalling axis drives therapy response
Tumour-derived WNT signals cause CAFs to produce activin A in responding patients. This chemical enhances CD8+ T cell stemness and improves sensitivity to anti-PD-1 treatment.
Non-responders show different pathways
A subset of CAFs that do not respond to WNT signals fails to produce activin A. This lack of production leads to impaired T cell function and resistance to therapy.
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