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Patients stop long-term medication due to fear of dependency and loss of control

A clinical pharmacist explains that patients often discontinue prescribed drugs because they worry about becoming dependent on daily treatment rather than just forgetting doses or fearing side effects.

Opinion: I thought I knew why patients stopped taking their medicine. I was wrong
File photo Opinion: I thought I knew why patients stopped taking their medicine. I was wrong Photo: STAT

Common reasons for stopping drugs

Healthcare professionals previously believed patients forgot medications or suffered from side effects. New conversations revealed that many individuals felt they were losing control of their bodies by needing daily treatment. This fear led them to stop taking antipsychotics, antidepressants, and immunosuppressants.

Specific medical consequences observed

Stopping antipsychotics caused psychotic episodes in patients with schizophrenia. Abruptly discontinuing antidepressants resulted in withdrawal symptoms for those users. Patients who ceased immunosuppressant use faced acute rejection of their new kidneys.

Patterns across different specialties

Doctors in cardiology and primary care described similar experiences with patients stopping treatment. Colleagues noted that initial explanations like forgetting were often easier answers for both parties. Longer discussions helped patients admit guilt and shame lessened their resistance to explaining true reasons.

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