New blood test DENEB detects early colorectal cancer and polyps in trials
Researchers published results for an experimental blood test called DENEB that detected early-stage colorectal cancers and precancerous polyps in a multicenter study released on August 10.
Study findings on cancer detection
The diagnostic study found the test identified 92 percent of stage I through III colorectal cancers. This performance was measured against colonoscopy results in a group of more than 1,500 adults participating in screening programs.
Performance regarding precancerous lesions
The test also detected 81 percent of advanced adenomas which are considered high-risk polyps. Ajay Goel noted that many existing blood tests struggle to find these precursor lesions while focusing on cancer.
Current status and limitations
Experts state the test remains experimental and requires more research before routine recommendation. Colonoscopy and stool-based tests continue to serve as the gold standard for screening colorectal cancer.
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