Hungarian researchers propose framework to predict antibiotic resistance risks early in drug development
Researchers from HUN-REN BRC Szeged and HCEMM published a review in Nature Reviews Microbiology proposing a five-step decision-making framework to identify resistance risks before clinical trials.
Current assessment limitations in development
Drug candidates are currently assessed for efficacy and safety early in the process. Evaluation of how readily bacteria evolve resistance often happens much later when changes are nearly impossible to make. A new antibiotic may perform well in the laboratory but fail during clinical trials as bacteria evolve resistance.
Five-step framework proposed by authors
The review authors Csaba Pál, Petra Szili and Szilvia Juhász propose a five-step decision-making framework to address these issues. Beyond assessing how readily resistance can emerge, the framework examines whether resistance persists without antibiotics or makes pathogens more dangerous. It also checks if resistance reduces the effectiveness of other drugs or involves genes with spread potential.
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