Georgia Tech and Emory researchers improve gut mRNA delivery targeting
Researchers at Georgia Tech and Emory University published a study in ACS Nano showing that oral lipid nanoparticle delivery can target specific gastrointestinal organs while reducing toxicity elsewhere.
Targeting organs via the GI tract
Scientists discovered that delivering lipid nanoparticles directly to different areas of the gastrointestinal tract changes where therapies travel after absorption. This method allows treatments to reach organs that are difficult to target using traditional injection methods. The approach simultaneously reduces uptake in organs normally associated with toxicity.
Potential benefits for vaccines and drugs
The study suggests oral mRNA delivery could enhance patient experience compared to injections. It may enable improved treatments or completely new therapies for conditions requiring precise targeting. Several technologies currently in development include pills, patches, and endoscopic injections.
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